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Glanzmann Thrombasthenia Description Impaired platelet aggregation from genetic deficiency of GpIIb/IIIa Etiology Autosomal recessive inheritance Mechanism ↓ GpIIb/IIIa (a platelet integrin) → Defect in platelet plug formation Symptoms and Signs Bleeding from mucous membranes Epistaxis, petechiae/purpura Laboratory ↑ Bleeding time Normal PT/PTT Normal platelet count and morphology Treatment Platelet transfusions with HLA-matched and leukocyte depleted blood products […]

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Glanzmann Thrombasthenia Description Impaired platelet aggregation from genetic deficiency of GpIIb/IIIa Etiology Autosomal recessive inheritance Mechanism ↓ GpIIb/IIIa (a platelet integrin) → Defect in platelet plug formation Symptoms and Signs Bleeding from mucous membranes Epistaxis, petechiae/purpura Laboratory ↑ Bleeding time Normal PT/PTT Normal platelet count and morphology Treatment Platelet transfusions with HLA-matched and leukocyte depleted […]

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