Glanzmann Thrombasthenia
- Impaired platelet aggregation from genetic deficiency of GpIIb/IIIa
- Autosomal recessive inheritance
- ↓ GpIIb/IIIa (a platelet integrin) → Defect in platelet plug formation
- Bleeding from mucous membranes
- Epistaxis, petechiae/purpura
- ↑ Bleeding time
- Normal PT/PTT
- Normal platelet count and morphology
- Platelet transfusions with HLA-matched and leukocyte depleted blood products
- Supportive care (iron and folate supplementation)
- Bernard-Soulier (↓ platelet count, ↑ bleeding time, and ↓ GpIb)
- ITP (↓ platelet count, ↑ bleeding time, and anti-GpIIb/IIIa antibodies)
- TTP (↓ platelet count, ↑ bleeding time, and defet/deficient ADAMTS 13)
